Free Radical Toxicology

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Kendall B Wallace
CRC Press, Jun 19, 1997 - 352 páginas
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Provides insight into the involvement of free radicals in the pathogenesis of chemical-induced toxic tissue injury. The text addresses the fundamentals of free radical chemistry and the theoretical basis for electron transfer reaction leading to free radical generation. It describes the various subcellular sources of free radicals, the biological reactivity with lipid, protein and nucleic acids, and the physiochemical determinants of free radical-induced cell injury and the various antioxidant defence systems. The book focuses on target organ toxicity, and the concluding section offers an overview of the evidence implicating free radicals in the aetiology of various chemical toxicities, challenging the possibility of misguided use of biomarkers for oxidative damage.
 

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Contenido

The Chemical Reactivity of Radicals
3
Physical Chemical Determinants of Xenobiotic FreeRadical GenerationThe Marcus Theory of Electron Transfer
15
Subcellular Sites of XenobioticInduced FreeRadical Generation
25
Biological Reactivity of Free Radicals
45
Formation and Biological Reactivity of Lipid Peroxidation Products
47
FreeRadicalMediated Modification of Proteins
71
FreeRadicalMediated DNA Oxidation
89
Physicochemical Determinants of FreeRadical Cytotoxicity
115
FreeRadicalMediated Chemical Cardiomyopathies
205
FreeRadicalMediated Toxic Injury to the Nervous System
221
FreeRadicalMediated Hematopoietic Toxicity by Drugs Environmental Pollutants and Ionizing Radiation
249
Selected Examples of FreeRadicalMediated Lung Injury
279
Activation of the Inflammatory Response by Asbestos and Silicate Mineral Dusts
295
Molecular and Cellular Aspects of FreeRadical Toxicity
323
FreeRadicalMediated Alterations of Gene Expression by Xenobiotics
325
FreeRadicalInduced Changes in Cell Signal Transduction
349

FreeRadical Defense and Repair Mechanisms
141
Selected Examples of FreeRadicalMediated Tissue Injury
173
FreeRadicalMediated Liver Injury
175
FreeRadicalMediated Kidney Injury
185
FreeRadical OxygenInduced Changes in Chemical Carcinogenesis
375
Markers of FreeRadicalMediated Tissue Injury Tales of Caution and Woe
401
Index
421
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