Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Agustín Ibáñez, Lucas Sedeño, Adolfo M. García, Robert M.J. Deacon, Patricia Cogram
Frontiers Media SA, 2018 M06 21

 Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. 

This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.



Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America
An Emergent Silent Tsunami
Epidemiological Evidence and Implications for Public Policy
Dementia Preclinical Studies in Neurodegeneration and its Potential for Translational Medicine in South America
Memory Alteration Test to Detect Amnestic Mild Cognitive Impairment and Early Alzheimers Dementia in Population with Low Educational Level
Feature Binding of Common Everyday Items Is Not Affected by Age
Behavioral and Psychological Symptoms Impact Clinical Competence in Alzheimers Disease
Adding Recognition Discriminability Index to the Delayed Recall Is Useful to Predict Conversion from Mild Cognitive Impairment to Alzheimers Dis...
A New Strategy in Mild Cognitive Impairment?
Enhanced Working Memory Binding by Direct Electrical Stimulation of the Parietal Cortex
Brain Transcriptome Sequencing of a Natural Model of Alzheimers Disease
Identification of Cerebral Metal Ion Imbalance in the Brain of Aging Octodon degus
Identification of Cerebral Metal Ion Imbalance in the Brain of Ageing Octodon degus
Early CognitiveSocial Deficits and Late Motor Phenotype in Conditional WildType TDP43 Transgenic Mice
Differences in Motor Behavior Tyrosine Hydroxylase and Synuclein Expression
A Novel Genetic Screen Identifies Modifiers of AgeDependent Amyloid Toxicity in the Drosophila Brain

WholeBrain Atrophy Differences between Progressive Supranuclear Palsy and Idiopathic Parkinsons Disease
Variants in SNCA Gene Are Associated with Parkinsons Disease Risk and Cognitive Symptoms in a Brazilian Sample
Relationship between Cognitive and SleepWake Variables in Asymptomatic Offspring of Patients with LateOnset Alzheimers Disease
Differences on Brain Connectivity in Adulthood Are Present in Subjects with Iron Deficiency Anemia in Infancy
Mitochondrial Functional Changes Characterization in Young and Senescent Human Adipose Derived MSCs
XBP1 Is a CellNonautonomous Regulator of Stress Resistance and Longevity
A Translational Perspective
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