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Página 69
Carcinogenesis , mutagenesis , impairment of fertility : Celecoxib was not carcinogenic in rats given oral doses up to 200 mg / kg for males and 10 mg / kg for females ( approximately 2- to 4 - fold the human exposure as measured by the ...
Carcinogenesis , mutagenesis , impairment of fertility : Celecoxib was not carcinogenic in rats given oral doses up to 200 mg / kg for males and 10 mg / kg for females ( approximately 2- to 4 - fold the human exposure as measured by the ...
Página 82
The low doses in mice and rats are approximately 1000 and 500 times greater , respectively than the daily human dose of one drop ( 28 μL ) of 0.05 % RESTASIS BID into each eye of a 60 kg person ( 0.001 mg / kg / day ) , assuming that ...
The low doses in mice and rats are approximately 1000 and 500 times greater , respectively than the daily human dose of one drop ( 28 μL ) of 0.05 % RESTASIS BID into each eye of a 60 kg person ( 0.001 mg / kg / day ) , assuming that ...
Página 14
In the 24 - month oral ( diet ) rat study , conducted at 0.5 , 2. and 8 mg / kg / day . pancreatic islet cell adenomas ... The low doses in mice and rats are approximately 1000 and 500 times greater , respectively , than the daily human ...
In the 24 - month oral ( diet ) rat study , conducted at 0.5 , 2. and 8 mg / kg / day . pancreatic islet cell adenomas ... The low doses in mice and rats are approximately 1000 and 500 times greater , respectively , than the daily human ...
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