Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We UseOxford University Press, 2006 M09 7 - 336 páginas The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful. |
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... extract. A few weeks later, the chicken developed the same type of cancer at the injection area. This was possibly the first time that a tumor was artificially produced in an animal using a tumor virus, which was later named the Rous ...
... extract. A few weeks later, the chicken developed the same type of cancer at the injection area. This was possibly the first time that a tumor was artificially produced in an animal using a tumor virus, which was later named the Rous ...
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... extract, many rabbits died of an overwhelming infection induced by Pseudomonas bacterium. Most people would have given up on the project after this disastrous outcome, but Noble and Beer dug deeper. They found that rabbits treated with ...
... extract, many rabbits died of an overwhelming infection induced by Pseudomonas bacterium. Most people would have given up on the project after this disastrous outcome, but Noble and Beer dug deeper. They found that rabbits treated with ...
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... extracts and found them to be cytotoxic. The potential anticancer properties prompted Barclay to go back to the Northwest and collect an additional 30 pounds of the precious stem bark of Taxus brevifolia. In 1966, after being rejected ...
... extracts and found them to be cytotoxic. The potential anticancer properties prompted Barclay to go back to the Northwest and collect an additional 30 pounds of the precious stem bark of Taxus brevifolia. In 1966, after being rejected ...
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... extract so that the cytotoxic potency increased 1,000-fold. In 1967, they isolated the active principle as white crystals in a 0.014% yield from the dry bark. The molecule was later determined to have a molecular formula of C 47H51 NO4 ...
... extract so that the cytotoxic potency increased 1,000-fold. In 1967, they isolated the active principle as white crystals in a 0.014% yield from the dry bark. The molecule was later determined to have a molecular formula of C 47H51 NO4 ...
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Contenido
3 | |
2 Drugs to Kill Germs | 43 |
From Nitroglycerin to Lipitor | 75 |
4 Sex and Drugs | 103 |
5 Drugs of the Mind | 129 |
6 Diabetes Drugs | 165 |
7 Anesthetics | 187 |
8 AntiInflammatory Drugs | 213 |
9 Reflections | 241 |
Chemical Structures | 245 |
Trademarks of the Drugs | 277 |
Bibliography | 281 |
Index | 295 |
Otras ediciones - Ver todas
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Vista previa limitada - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Vista previa limitada - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories Behind the Drugs We Use Jie Jack Li Vista previa limitada - 2006 |
Términos y frases comunes
ACE inhibitors acid active agents alcohol anesthesia anesthetic antibacterial antibiotics antidepressants aphrodisiac approved aspirin Avastin Banting barbiturates became beta-blockers biological blood breast cancer Bristol-Myers Squibb calcium cancer drugs cause cells Chain chemical chemist chemistry chemotherapy chloroform chlorpromazine cholesterol clinical trials cocaine compounds cortisone depression developed diabetes discovered disease doses drug discovery EGFR enzyme estrogen ether extract Florey Gleevec guinea pigs haloperidol heart hormone human inhibit inhibitors initially injection insulin Iressa isolated kinase laboratory later leukemia leukotriene Lilly Lipitor lithium liver Macleod Marsilid medicine Merck metabolism mevastatin million molecule Morton nitroglycerin nitrous oxide Nobel Prize Novartis oral pancreas Parke-Davis patients penicillin Pfizer pharmaceutical Physiology production Prontosil prostaglandin protease protein Prozac receptor rheumatoid arthritis Roche scientists serotonin side effects Squibb statins streptomycin sulfanilamide Syntex synthesis tamoxifen Taxol tested therapy tion toxic trade name treating treatment tuberculosis tumors University Viagra virus Waksman