The Reader's Digest, Volumen171Reader's Digest Association, 2007 |
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Página 17
... mg / kg / day were 55 times higher than the AUC0-24hr level in breast cancer patients at the recom- mended dose . The carcinogenicity study in rats at oral doses of 0.1 to 10 mg / kg / day ( about 0.4 to 40 times the daily maximum recom ...
... mg / kg / day were 55 times higher than the AUC0-24hr level in breast cancer patients at the recom- mended dose . The carcinogenicity study in rats at oral doses of 0.1 to 10 mg / kg / day ( about 0.4 to 40 times the daily maximum recom ...
Página 24
... mg twice daily was administered for 3 days prior to single - dose co ... day of ketoconazole 200 mg twice daily administration , compared to ... kg ) , there were no clinically meaningful or statistically significant effects on ...
... mg twice daily was administered for 3 days prior to single - dose co ... day of ketoconazole 200 mg twice daily administration , compared to ... kg ) , there were no clinically meaningful or statistically significant effects on ...
Página 25
... mg / kg / day . No effects on male or female mating or fertility were observed with a ramelteon dose up to 600 mg / kg / day ( 786 - times higher than the MRHD on a mg / m2 basis ) . Irregular estrus cycles , reduction in the number ...
... mg / kg / day . No effects on male or female mating or fertility were observed with a ramelteon dose up to 600 mg / kg / day ( 786 - times higher than the MRHD on a mg / m2 basis ) . Irregular estrus cycles , reduction in the number ...
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