The Reader's Digest, Volumen171Reader's Digest Association, 2007 |
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Página 17
... rats at oral doses of 0.1 to 10 mg / kg / day ( about 0.4 to 40 times the daily maximum recom- mended human dose on a mg / m2 basis ) for up to 2 years also produced an increase in the incidence of benign ovarian stromal tumors at 10 mg ...
... rats at oral doses of 0.1 to 10 mg / kg / day ( about 0.4 to 40 times the daily maximum recom- mended human dose on a mg / m2 basis ) for up to 2 years also produced an increase in the incidence of benign ovarian stromal tumors at 10 mg ...
Página 24
... rat , male and female rats were administered ramelteon at doses of 0 , 15. 60 , 250 or 1000 mg / kg / day by oral gavage Male rats exhibited a dose - related increase in the incidence of hepatic adenoma and benign Leydig cell tumors of ...
... rat , male and female rats were administered ramelteon at doses of 0 , 15. 60 , 250 or 1000 mg / kg / day by oral gavage Male rats exhibited a dose - related increase in the incidence of hepatic adenoma and benign Leydig cell tumors of ...
Página 25
... rats for 7 weeks had no effect on sperm quality and when the treated male rats were mated with untreated female rats there was no effect on implants or embryos . In a repeat of this study using oral administration of ramelteon at 20. 60 ...
... rats for 7 weeks had no effect on sperm quality and when the treated male rats were mated with untreated female rats there was no effect on implants or embryos . In a repeat of this study using oral administration of ramelteon at 20. 60 ...
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