On Vaccine Inoculation

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R. Phillips, 1806 - 108 páginas

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Página 7 - ... to the nipple of the cow, and from the cow to the human subject. Morbid matter of various kinds, when absorbed into the system, may produce effects in some degree similar; but what renders the cow-pox virus so extremely singular is that the person who has been thus affected is forever after secure from the infection of the smallpox; neither exposure to the variolous effluvia, nor the insertion of the matter into the skin, producing this distemper.
Página 73 - A more healthy description,' says this gentleman, ' of human beings does not exist, nor one more free from chronic cutaneous impurities, than that which suffers most from cow-pox, by reason of their being employed in dairies; and the Gloucester Infirmary, one of the largest provincial hospitals, is situated in a county in which accidental cow-pox has been prevalent from time immemorial ; many hundreds among the labouring people have had the cow-pox since the establishment of that institution, and...
Página 95 - ... infection, and for purifying any ship or house in case any contagious disorder shall manifest itself in any part of the United Kingdom, notwithstanding the precautions taken to guard against the introduction thereof : and to communicate the same to all magistrates, medical persons, and others, his Majesty's subjects, who may be desirous and may apply to be made acquainted with the same.
Página 13 - It does not appear," says Dr. Willan, who minuted the cases as they happened, "that failures in the preventive effect of vaccine inoculation, including mistakes, negligences, and misstatements, have occurred in a greater proportion .than as one to eight hundred"* It is very improbable, then, that the actual failures amount to one in a thousand, or to any thing near that number. But let us suppose, for the sake of argument, that the failures amount to the proportion of one in five hundred; that is...
Página 27 - ... sixth day, instead of shewing a beginning vesicle, which is usual in the cow-pox at that period, was encrusted over with a rugged, ambercoloured scab. The scab continued to spread and increase in thickness for some days, when, at its edges, a vesicated ring appeared, and the disease went through its ordinary course, the boy having had soreness in the axilla and some slight indisposition. With the fluid matter taken from his arm five persons were inoculated. In one it took no effect. In another...
Página 27 - ... through its ordinary course, the boy having had soreness in the axilla and some slight indisposition. With the fluid matter taken from his arm five persons were inoculated. In one it took no effect. In another it produced a perfect pustule without any deviation from the common appearance; but in the other three the progress of the inflammation was exactly similar to the instance which afforded the virus for their inoculation ; there was a creeping scab of a loose texture, and subsequently the...
Página 4 - That these effects took place, without much variation, in all cases where the interval between the two inoculations did not exceed a week; but, 3. " That when variolous matter was inserted on the ninth day after the vaccine inoculation, its action seemed to be wholly precluded," (the system being now sufficiently fortified against it by the due protecting effects of cow-pox).
Página 30 - The areola appears (earlier) round these vesicles, on the seventh or eighth day after inoculation, and continues more or less vivid for three days, during which time the scab is completely formed. The scab is smaller and less regular than that which succeeds the genuine vesicle ; it also falls off much sooner, and, when separated, leaves a smaller cicatrix, which is sometimes angulated. The third irregular appearance is a vesicle without an areola.
Página 84 - ... are on the fifth or sixth day, especially where there happens to be a larger space than ordinary occupied by the extravasated serum. It happens to most of them, either on the first day that this little bladder arises, or on the day after, that its tender cuticle is burst by the accidental rubbing of the clothes, or by the patient's hands to allay the itching which attends this eruption. A thin scab is then formed at the top of the pock, and the swelling of the other part abates, without...
Página 34 - Although the susceptibility of the virus of the cowpox is, for the most part, lost in those who have had the smallpox, yet in some constitutions it is only partially destroyed, and in others it does not appear to be in the least diminished. By far the greater number on whom trials were made resisted it entirely; yet I found some on whose...

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