The Reader's Digest, Volumen157Reader's Digest Association, 2000 |
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Página 39
... mg / kg / day , a dose which resulted in a mean plasma drug level similar to that seen with the 60 mg / kg / day dose . Carcinogenesis , Mutagenesis , Impairment of Fertility : In a 2 - year study in rats fed pravastatin at doses of 10 , 30 ...
... mg / kg / day , a dose which resulted in a mean plasma drug level similar to that seen with the 60 mg / kg / day dose . Carcinogenesis , Mutagenesis , Impairment of Fertility : In a 2 - year study in rats fed pravastatin at doses of 10 , 30 ...
Página 62
... mg / kg / day . Brain hemorrhage and optic nerve vacuolation were seen in another female dog that was sacrificed in moribund condition after 11 weeks of escalating doses up to 280 mg / kg / day . The 120 mg / kg dose resulted in a ...
... mg / kg / day . Brain hemorrhage and optic nerve vacuolation were seen in another female dog that was sacrificed in moribund condition after 11 weeks of escalating doses up to 280 mg / kg / day . The 120 mg / kg dose resulted in a ...
Página 63
... mg / kg / day or in rabbits at doses up to 100 mg / kg / day . These doses resulted in multiples of about 30 times ( rat ) or 20 times ( rabbit ) the human exposure based on surface area ( mg / m2 ) . In a study in rats given 20 , 100 , or ...
... mg / kg / day or in rabbits at doses up to 100 mg / kg / day . These doses resulted in multiples of about 30 times ( rat ) or 20 times ( rabbit ) the human exposure based on surface area ( mg / m2 ) . In a study in rats given 20 , 100 , or ...
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