The remedy, therefore, is regular and systematic administration of the serum.

When the serum treatment can not be carried out, or when you get the patient in the first day of the disease, the saline treatment is the most useful. Indeed, in many early cases it suffices for a complete cure. Two drachms each of magnesium sulphate and sodium sulphate dissolved in one ounce of water should be administered, and then half doses of a similar mixture should be given every hour or every two hours until the motions become feculent, after which it is given every three or four hours for another twenty-four hours and then discontinued; but do not stop it too soon, otherwise the patient will still suffer from fecal retention, even though he be passing a large number of stools containing only blood and mucus.

Up til recently our only method of treatment of amebic dysentery was by huge doses of ipecacuanha. This treatment, if persevered in, was undoubtedly efficacious, but the nausea caused by the drug was so severe that it was extremely difficult to persuade patients to take it. To remedy this a de-emetinized ipecacuanha was put on the market some years ago, but this proved to be useless, and they were reluctantly compelled to return to their old methods. Recently, however, the treatment of amebic dysentery has been revolutionized by the researches of Vedder in 1911 and by the discovery of Rogers that the amebae can be quickly killed by the hypodermic injection of emetin, and that, when given in this way, the patient experiences no nausea or discomfort of any kind. Both the hydrochloride and the hydrobromide of emetin are equally useful, but the former is more soluble, the latter requiring 2 Cc. of sterile water or saline for the solution of one dose. Rogers begins with grain, which is equal to 30 grains of ipecacuanha, but he now gives one grain of emetin each day, in two hypodermic doses of 1⁄2 grain each, and he claims that by this method all the amebae in the body can be killed in from two to four days, the average for a number of cases being 2.35 days. He has also

shown that one or two grain tablets may be given by the mouth on an empty stomach without exciting any great nausea, especially if they are keratincoated. This method of administration does not effect a cure as speedily as when the drug is given hypodermically, but it may be useful when for any reason there are difficulties in connection with the giving of the injections.

The hypodermic injection of emetin is also a valuable aid to diagnosis. If one has a case which is suspected to be amebic dysentery, but which does not react to emetin within three days, one may be sure that the diagnosis is wrong, and one need waste no further time in treating it as such. Moreover, the powerful effect of emetin on amebic cases, compared with its uselessness in bacillary cases, may be taken as strong proof that amebic dysentery is really a separate entity. That is why in the earlier part of this paper Lukis states that we might reject the view that intestinal amebae play no part in the causation of this disease.

This is taken from the Charlotte Medical Journal.

A recent issue of the British Medical Journal says that James A. Raeburn was prompted to try the subcutaneous injections of emetin in pulmonary tuberculosis as a result of observations of Flandrin and Joltrain, who reported that its use checked many cases of hemoptysis. Raeburn confirmed their observations; he goes farther and finds that emetin seems to have considerable power of checking bronchitis, often causing its complete disappearance. It seems not to have any influence on the presence of bacilli in the sputum, or on the tuberculin reaction, its effect being solely on the bronchial inflammation. When there is a weak heart the drug should not be used, and in such cases its use has been found to be without beneficial influence on the bronchitis. He uses about 1.5 mgm. for the control of expectoration or to lessen the congestion of the bronchi. He has observed no ill effects with these doses.

Dr. G. W. McCasky, of Fort Wayne, reported in the Journal of the American Medical Association a case of amebic dys

entery of thirteen years' duration cured by the use of emetin hydrochloride.

S. E. Earp.

THERAPEUTIC NOTES.

Give pilocarpine nitrate hypodermatically in sciatica.

Read treats hiccough with ten-drop doses saturated vinous solution menthol, given in hot water every hour.

Brand treats gout with a paste of sodium bicarbonate. Make up a thick paste with a little water and apply thickly.

Schamberg treats vaccination sores with the following: Picric acid, 4 grams; iodine, 1 gram; alcohol, 100 grams. Paint parts.

An excellent sedative application is made as follows: Sodium chloride, 1 ounce; spirits of camphor, 1 fluid ounce; ammonia water, 2 ounces; water, 1 pint. Lecithin is stated to reduce the toxic power of strychnine, hydrated chloral morphine, veronal and alcohol, when administered with them.

Salvarsan suppositories have been worked out. Take of salvarsan and novocaine, of each 1 part; sweet almond oil, q. s. to suspend powder; cacao butter, 10 parts.

Dr. Forget says: Of all the expectorants the most effective is vomiting; it is indicated in all cases of chest trouble in which mucus obstructs the bronchi.

To abort a coryza in the beginning, mix two grains of finely powdered opium with one ounce of water. Shake the mixture well and snuff up the nostrils every two hours.

Queyrat recommends the following formula in the treatment of genital herpes: Menthol, 3 grains; guaiacol, 3 grains; zinc oxide, 30 grains; ointment of rose water, 5 drachms.

Stern suggests in nicotine poisoning the following: Adonidin, 1 grain; ammonium carbonate, 18 grains; camphor, 6 grains. Divide into 12 powders and administer one powder 3 times a day.

In the treatment of oxaluria, especially cases marked by anemia and nervous atony, Hazard recommends the follow

ing: Dilute hydrochloric acid, 4 fluid drachms; tincture of iron chloride, 2 fluid drachms; water and syrup, q. s. 8 fluid ounces. Teaspoonful doses.

Equal parts fluid extract stillingia, tr. belladonna, tr. nux vomica and tr. physostigma is a formula recommended in hemorrhoids consequent upon hepatic engorgement and intestinal atony. Administer 20 drops of the mixture in water before meals.-Medical Council.

PUERPERAL INFECTION TREATED WITH MAGNESIUM SULPHATE.

J. A. Harrar is of the opinion that in proper quantities and dilutions magnesium sulphate is absolutely harmless when administered intravenously to women suffering with puerperal infection. It is of more value early in the courses of the infection than after secondary localization has occurred. In the chronic cases of secondary theombophlebitis or pyemia it does not appear to be of benefit. Its action seems to be chiefly upon the organisms circulating in the blood.

Magnesium sulphate shortens the course of the bacterial toxemias in which the bacteria can not be demonstrated in the blood by culture, and anticipates the establishment of a bacteriemia.

In Harrar's forty-six cases of puerperal infection with blood cultures showing streptococci, previous to 1910, but three survived, a mortality of 93 per cent. In the five cases with positive blood cultures since 1910, treated with intravenous injections of magnesium sulphate, all but one have recovered, a reduction in the mortality from 93 to 20 per cent. While this is a small series upon which to base percentages, a perusal of the case reports and of the temperature charts will show that they were desperately ill patients, and of the class heretofore doomed to a fatal issue.American Journal of Obstetrics, November, 1913.

Feeling seedy, he went to his doctor,
And here's the advice he got:
"Indian clubs are good for the liver,
Bohemian clubs are not."

DR. SPOTSWOOD, NOW 88 YEARS OLD, A MEMBER OF INDIANA

LEGISLATURE OF 1853.

Dr. E. T. Spotswood, of Terre Haute, Ind., is believed to be the only living member of the Indiana Legislature of 1853, which favored a State-wide prohibition law. The current number of the American Issue says of the aged Terre Hautean:

"Dr. Spotswood, as a Nebraska Democrat, represented Vermilion county as a member of the house and voted for the enactment of this law, which two years later was repealed. While the vote on this bill was being taken in the house friends of the measure in the State House yard fired a cannon for each vote announced in favor of the bill. As soon as the measure passed, the speaker adjourned the house. The next day Dr. Spotswood learned that he had hardly left his seat when a hundred pounds of plastering, jarred loose, by the concussions, had fallen into his seat.

"Dr. Spotswood, who is now in his eighty-eighth year, is a direct descendant from Augustus Washington, who was a brother of George Washington. His paternal ancestor, Gen. Alexander Spotswood, was colonial Governor of Virginia. A daughter of General Spotswood, Dorothea, married a Nathaniel Danbridge, a descendant of Captain Bainbridge of the British navy. Their son, John Danbridge, became the father of Martha Danbridge, who was married first to John Park Custis, and, after his death, to George Washington.

"Dr. Spotswood graduated from Rush Medical College in 1851. In1905 he was one of the three oldest living graduates of that institution and may not be the oldest. He practiced medicine for fiftyfour years. During the Civil war he was the senior surgeon of the Seventy-first Indiana Volunteers, which was later changed to the Sixth Indiana Cavalry. The regiment lost 419 in battle and fifty starved in Andersonville prison. On ac

Shake

SHAKESPEARE. The recent anniversary of speare's birth reminds us that one of our local physicians, Dr. W. B. Clarke, published a very carefully prepared synopsis of Shakespeare's familiarity with Medicine. It consisted of quotations and many valuable comments. Favorable comment was made by the Indianapolis Sentinel December 11, 1898.

The conclusion of the essay relates to senility as follows:

Jaques, the philosophic Jaques, says: And so, from hour to hour, we ripe and ripe,

And then, from hour to hour, we rot and rot,

leading up to his famous and oft'-quoted "seven ages of man," "As You Like It," Act II, Scene 7, beginning:

All the world's a stage,

And all the men and women merely players,

and ending:

Last scene of all,

That ends this strange eventful history, Is second childishness, and mere obliv

ion;

Sans teeth, sans eyes, sans taste, sans everything.

But fail not to observe that this is the utterance of a cynic and hypochondriac. To me there is no more beautiful pic

ture, with its frame of purest silver, than the benign countenance of the aged man or woman who has learned the great lesson of life, to grow old gracefully, and who can say, with Dr. Holmes, I'd rather be seventy years young than forty years old. Let this, then, be our lesson and our ambition, and if we succeed we and the world will be the happier for our having done our part. And

So live that when thy summons comes to join

The innumerable caravan which moves To that mysterious realm where each

The commencement address to the class of 1914 is to be delivered by Dr. LeBaron R. Briggs, dean of Harvard University, on Wednesday, June 24. The baccalaureate address to the class will be delivered Sunday evening, June 21, by the Rev. Owen Odell, pastor of the Second Presbyterian Church of Indianapolis.

The Indiana University Alumni Association is also making arrangements for the reunion of the following classes during commencement week: '89, '94, '99, '04 and '09. Judge Robert VanAtta, of Marion, of the class of '93, will deliver the

DR.

AND MRS. R. W. LONG GIVE $10,000 ADDITIONAL.

Dr. and Mrs. Robert W. Long, donors to the Indiana University School of Medicine of the Robert W. Long Memorial Hospital, now being erected in West Michigan street, near White river, have added $10,000 to the money and property formerly given by them to the State institution for the completion of the building. This brings the total amount of the donations from Dr. and Mrs. Long up to $260,000, according to an estimate of the total value of property contributed by Dr. Long. The additional gift will be used to make the hospital more complete. A subcommittee of the board of trustees of Indiana University, in session at the Denison Hotel, was surprised when Dr. Long appeared and gave it a check for $10.000. None of the members of the committee knew that such a gift was contemplated.

Dr. and Mrs. Long gave property valued at approximately $200,000 to the Stat institution for a hospital in 1911 during the session of the Legislature. The Legislature accepted the gift, which was to be sold and the money received used to erect a hospital to bear the name of Robert W. Long. It was decided to issue $200,000 in bonds on this property and use the proceeds for the hospital. About a year ago Dr. Long gave the board of trustees $20,000 additional in bonds.

TRIBUTE TO THE MEMORY OF DR. REBECCA ROGERS GEORGE.

The Marion County Homeopathic Medical Society adopted resolutions on the death of Dr. Rebecca Rogers George, who died April 17, paying tribute to her both

as a physician and as a woman. The resolution follows:

"In the death of Dr. Rebecca Rogers George, the Marion County Homeopathic Medical Society has lost one of its most enthusiastic, members.

loyal and distinguished

"As a student she was persistent, untiring and thorough; as a practitioner she was conscientious and eminently successful. In her we recognized the highest type of womanhood as well as physician.

"Therefore, be it resolved, that our society, in session assembled, do hereby testify to her sterling worth as a physician, councilor and friend.

"Be it further resolved, that we hereby extend to her husband, family and friends our heartfelt sympathy in their great loss and bereavement."

The funeral of Dr. George was held at the family home, 1209 Broadway. The body was taken to Pendleton, Ind., her former home, for burial.

Over

March 31, 1914. City Hospital. Program: Case Report of Elephantiasis of Scrotum, by Dr. F. R. Charlton. This case is presented as elephantiasis for want of a more accurate term. 70 per cent. of oriental elephantiasis is easily demonstrable as due to the filaris sanguinis hominis. This parasite mechanically blocks the lymph vessels. Any cause producing such a lymphangiectasis may produce clinical elephantiasis, such as we see sporadically in cases have never been in the tropics. Hektoen & Riesman state that "this condition of the tissues, slight or moderate or occasionally severe, may arise from obstruction of the lymphatics from any cause such as may occur after repeated attacks of erysipelas, after lymphatic glands or from pressure of new growths."

that

removal of mechanical The present

case distinctly dates from an extensive crushing injury. Cases similar to this have been pronounced by the pathological department of this hospital, "keloidal granuloma," "keloidal tuberculoma," etc. Simple keloid should not be easily confused, but a primary keloid modified by extensive lymph blocking, becomes so far as gross clinical appearances are concerned, elephantiasis. Surgical removal is the only treatment offering relief and the results therefrom are surprisingly good.

Dr.

Case Report: Spinal Salvarsan. C. F. Neu showed cases receiving salvarsan intraspinally, calling attention to various methods used, some dangers that might follow, and the uncertainty of results of this treatment to date.

Case Report: Aortic Lesions. Dr. S. E. Earp. Dr. Earp presented three patients for demonstration. The first was a case of aortic regurgitation in which all characteristics were pronounced. A skigraph had been taken for the purpose of getting an accurate diagram on a bi-colored felt pattern. This was placed upon the body of the patient to illustrate the difference between the X-ray findings and the result of percussion; also to give an idea of the cor bovis. Attention was called to a failure of compensation when imperfection of the coronary vessels caused malnutrition of the myocardium. Cardiac hypertrophy in all its phases and Flints Murmur were discussed. It was also shown how there might be an absence of the Corrigan pulse due to dilatation of the ventricle or other defects. The second case was one of aortic regurgitation with a less pronounced water-hammer pulse, but a clear Flints Murmur, and the third case was one of mitral stenosis and mitral regurgitation.

"Demonstration of New Instruments for Removal of Adenoids and Tonsils," by Dr. Lafayette Page.

In removing tonsils by dissection one of the chief difficulties is obtaining an instrument that will hold the tonsil securely. The forceps shown, designed by me, has proved most satisfactory. The tissues are crowded together between the